Publications – Byrne Research Group

28 June, 20251 October, 2025 Joe news, Publications

New publication: Metallodrugs in OBC

𝗠𝗲𝘁𝗮𝗹 𝗰𝗼𝗺𝗽𝗹𝗲𝘅𝗮𝘁𝗶𝗼𝗻 𝗰𝗮𝗻 𝗺𝗼𝗱𝘂𝗹𝗮𝘁𝗲 𝘁𝗵𝗲 𝗯𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 𝗼𝗳 𝗴𝗹𝘆𝗰𝗼𝗰𝗼𝗻𝗷𝘂𝗴𝗮𝘁𝗲 𝗹𝗶𝗴𝗮𝗻𝗱𝘀 𝗮𝗴𝗮𝗶𝗻𝘀𝘁 𝗽𝗮𝘁𝗵𝗼𝗴𝗲𝗻𝘀!
Delighted to have another article on glyco-metal complexes published in 𝘖𝘳𝘨𝘢𝘯𝘪𝘤 & 𝘉𝘪𝘰𝘮𝘰𝘭𝘦𝘤𝘶𝘭𝘢𝘳 𝘊𝘩𝘦𝘮𝘪𝘴𝘵𝘳𝘺. This work was led by Karolina Wojtczak, PhD and involved contributions and support from lots of colleagues across disciplines including the teams of Trinidad Velasco-Torrijos, Anne Imberty, Gordon Cooke (TUD), Dr. Cristina Trujillo and Kevin Kavanagh who put lots of work into ideas, assays, measurements and calculations to support our hypotheses.

Please read the full article in the RSC journal Organic and Biomolecular Chemistry, where it will be part of the 2025 New Talent Special Issue: https://doi.org/10.1039/D5OB00970G

Buíochas le Taighde Éireann Research Ireland as ucht tacaíocht.

19 June, 202326 July, 2023 Joe Publications

ChemComm: Terbium-based lectin sensors

Congratulations to Karolina on her first article published in Chemical Communications. The article has been included in the HOT Articles 2023 Collection as well as a themed collection on Chemosensors and Molecular Logic (related to last year’s MSMLG Conference). The work was considered exciting by the editors and so was featured on the Front Cover of the journal issue.

We describe glycoconjugate terbium(III) complexes, which are able to detect carbohydrate-binding proteins in aqueous buffer solution. When the carbohydrate motif on the complex matches the target of the protein, an enhancement in lanthanide luminescence is observed. The bacterial lectin LecA (from P. aeruginosa) is one of the detected proteins.

Sensing behaviour of complexes **Tb.3**. See article for full description of results

This work was funded by Science Foundation Ireland (18/SIRG/5501), with support from a 4th year project student, and our collaborators in TU Dublin (Gordon Cooke) and University of Saarland (Alexander Titz, HZI/HIPS). The interdisciplinary work includes synthesis of new sensor molecules, biological assessment and examination of their lectin binding affinity. We believe this work could lead to the development of tools which could use detection of characteristic proteins from pathogens as a means for diagnosis, and hope to follow up on this in future publications.

15 April, 2022 Joe Publications

Article on lectin-inhibitors published in ChemMedChem

Karolina and Joe’s review article on “Structural considerations for building synthetic glycoconjugates as inhibitors for Pseudomonas aeruginosa lectins” has been published by ChemMedChem. The article is available here: https://doi.org/10.1002/cmdc.202200081

Pseudomonas aeruginosa is a pathogenic bacterium, responsible for a large portion of nosocomial infections globally and designated as critical priority by the World Health Organisation. Its characteristic carbohydrate-binding proteins LecA and LecB, which play a role in biofilm-formation and lung-infection, can be targeted by glycoconjugates. In the review, we present the wide range of inhibitors for these proteins (136 references), highlighting structural features and which impact binding affinity and/or therapeutic effects, including carbohydrate selection; linker length and rigidity; and scaffold topology, particularly for multivalent candidates. We also discuss emerging therapeutic strategies, which build on targeting of LecA and LecB, such as anti-biofilm activity, anti-adhesion and drug-delivery, with promising prospects for medicinal chemistry.

This article would be a good entry-point for any researchers considering tackling P. aeruginosa as a target organism, particularly if they want to build lectin-targeting ligands building on the existing consensus in the field on the best structural features to ensure high lectin affinity.

Thanks to Science Foundation Ireland for funding this research.

5 May, 20215 May, 2021 Joe Publications

New article in RSC Advances: Glycoclusters with anti-biofilm activity

Our new article, published in RSC Advances (a Gold Open Access journal), describes a series of new ruthenium-centred glycoclusters, which present four carbohydrate motifs around a three-dimensional octahedral scaffold. Multivalent glycoclusters have previously shown the ability to inhibit the carbohydrate-binding proteins which are produced by bacterium P. aeruginosa. Gordon Cooke’s group in TU Dublin tested these new compounds for their ability to inhibit growth of biofilm by P. aeruginosa and we observed that complex 8Gal, with flexible arms between the scaffold core and the galactose motif gave up to 80% inhibition of biofilm, when compared to the control – the other complexes and the ligand did not show antimicrobial activity. We propose that this activity is due to the ability of galactose to interact with the carbohydrate-binding protein LecA.

We thank Science Foundation Ireland for financial support for this work, as well as UCD School of Medicine’s SSRA Scheme, where preliminary studies began.

15 September, 202018 September, 2020 Joe Publications

New organocatalysis paper in OBC

In new research, carried out in University of Bern, we have shown that triazolium iodides are excellent catalysts for the oxidative coupling of benzylamines, due to a synergistic cation/anion effect, with iodide acting as I⁻/I₂ redox manifold and the triazolium cation facilitating the iodine reduction and concomitant substrate oxidation. Oxygen was is the terminal oxidant for this process.

The article is available at: https://doi.org/10.1039/D0OB01472A (Open access in Organic and Biomolecular Chemistry, Themed Collection: Catalysis and Biocatalysis in OBC)

The research emerged from the dual interest in the Albrecht group in catalysis and the use of triazolium salts – typically as precursors to organometallic complexes. Joe followed up on some unexpected catalytic activity of triazolium iodides with a series of experiments and control experiments to determine the origins of the reactivity, the role of atmospheric oxygen as terminal oxidant, the importance of the iodide/iodine redox couple and the accelerating effect of the triazolium ion. We hope this work will inspire others to look at the role of heterocylcic compounds in other processes catalysed by iodine.

22 April, 202024 May, 2020 Joe Publications

New paper in ChemCatChem

Joe was part of a collaborative project between University of Bern (Switzerland) and Universitat Jaume I (Spain), which was recently published in ChemCatChem. This work describes the use of mesoionic iridium(III)-NHC complexes as catalysts for efficient dehydrogenation of carbohydrates in water. Without the need for additives, these complexes compare were to previous work published by Dr Jose Mata’s group, using imdazolylidene iridium(III) complexes, along with sulfuric acid.

Introducing abnormal triazolylidene NHC complexes from the Albrecht lab, allowed for this further enhancement of activity for this interesting reaction, which releases hydrogen from carbohydrate substrates, giving only the carbohydrate acid (e.g. gluconic acid) as a by-product, which has potential utility as a initial platform chemical for further synthesis, derived from biomass feedstocks.

19 July, 20191 May, 2020 Joe Publications

New publication in Dalton Transactions

I’m delighted to finally publish this work, the first of my research carried out during my Marie Curie Fellowship in University of Bern to come out. A lot of hard work by Erasmus student Pauline went into gathering data behind this manuscript where we asked the question – what impact would incorporating carbohydrates into the structure of a Ruthenium(II)-triazolylidene complex have on its ability to convert a ketone to an alcohol via transfer hydrogenation catalysis.

There were challenges in isolating the desired compound, so it had to be generated in situ, but we were able to assess the activity, and the results were interesting, and can be found in detail here in Dalton Transactions.

To summarise the conclusions: The carbohydrate functionality does impact catalytic activity (transfer hydrogenation of ketones). In complexes with the glucose directly triazolylidene-bound, turnover rates were substantially higher when compared to more remote carbohydrate functionalisation (i.e. with an ethylene spacer). Both new complexes, however, have reduced activity compared to unfunctionalised carbene complexes. Insight was also gained into the nature of the catalytic cycle through a substrate scope analysis.