Joe news, Team

Welcome to Rosa, Finn and Hubert

This Autumn we welcome three new members to the Byrne Research Group. The group, at 6 full-time researchers, is the largest it has been to date! Welcome to Rosa, Finn and Hubert – we wish them every success.

Dr Rosa Fernandez Pison joins us as a postdoctoral researcher on the Link4Lectin project, where she will contribute to the coordination chemistry and organometallic components of the target molecules. She completed her PhD in UCD during the summer in organometallic catalyst development. She previously completed a Research MSc at University of Galway, and an undergraduate degree in her native Sevilla (with year abroad in University of York).

Finn Tlatlik holds an MSci from University of Glasgow in Chemistry with Medicinal Chemistry. His degree included a year of research placements in France as well as a project in Glasgow. He is joining us to complete his PhD with a Sir Walter Hartley Studentship, and will be working on optimising the photophysical properties of lanthanide complexes as lectin sensors.

Hubert Rebow is returning to the group, having secured a Government of Ireland Postgraduate Scholarship. Hubert is a recent graduate of UCD’s Medicinal Chemistry and Chemical Biology BSc programme, and completed a final year project in our lab. His project, developing supramolecular boronic acid-based glycan probes involves collaboration with Dr Aniello Palma and Prof Jeremy Simpson.

Joe Team, Visitors

Catherine completes RISE internship

Catherine Chaita, a third-year Pharmaceutical Science students from TU Dublin in Tallaght, joined the lab for two-weeks this summer as part of the RSC RISE Programme, designed to retain, inspire, support, and enhance ethnically-underrepresented groups in the chemical sciences. Catherine had a placement at TU Dublin last summer and came to us this summer. She fit in really well and quickly picked up a lot of skills under Thomas’ tutelage (and contributed to the Link4Lectin project). Catherine had the following to say about her experience:

In the second year [of the RISE programme], I was offered a two-week summer internship at University College Dublin (UCD), where I had the opportunity to work in the laboratory of Professor Joe Byrne, whose research focuses on sugars and inorganic/organic chemistry.
During the internship, I worked under the mentorship of PhD graduate Thomas Rabbitte who guided me through a variety of hands-on experiments. I was actively involved in various research projects. This experience greatly enhanced my technical and analytical skills, as I was introduced to a range of instruments and laboratory techniques relevant to pharmaceutical science. I carried out several chemical reactions, including alkylation, click chemistry, and amide coupling reactions.
The lab environment was collaborative and inspiring, with a team of postgraduate researchers and undergraduate interns all contributing to ongoing sugar-related research. My time at UCD provided me with a solid foundation of practical skills and deeper insight into real-world pharmaceutical and chemical research, and it further fueled my interest in pursuing a career in the pharmaceutical industry.

We wish Catherine every success with the rest of her studies and her future career in chemistry and hope to see her again.

Well done to Catherine Chaita for completing an intership with us as part of the RISE programme
Joe Team

Rosy graduates!

Congratulation to Dr Rosy Polisicchio on her graduation from University of Galway today! Rosy’s thesis was titled “Lanthanide-functionalised vitamin B12 probes for targeted tumour bio-imaging: from rational design to biological evaluation” and her primary supervisor was Dr Luca Ronconi. Joe was her secondary supervisor, lending his expertise on lanthanide chemistry. Rosy was supported by a Hardiman Scholarship and later won an IRC Government of Ireland Postgraduate Scholarship. She was also active in outreach during her PhD. Rosy has already started as an R&D Scientific Communication Advisor at Unilever in the UK. We wish Rosy every success in her future career!

Joe Team, Visitors

Romain completes his Erasmus+ internship with the group

Farewell to Romain Neveu, who is returning to his home university in France after a 4-month training mobility visit to our lab. Romain became a well-integrated member of the group and helped progress our investigations into fluorescent boronic acid derivatives.

Romain had the following to say about his visit:

I’m currently in my second year at ENSICaen, studying Materials-Chemistry with a major in Organic Chemistry and Catalysis (Master 1 level), and had the opportunity to do a four-month internship in Ireland as part of my Erasmus program. My main aim was to improve my English and technical skills, so I explored a number of Irish universities.
I discovered UCD and the Byrne Group on the university website, which focuses on carbohydrates and inorganic chemistry. I was particularly interested in this field, which led me to contact Joe Byrne.
During my internship, I worked on the synthesis of boronic acids and studied their fluorescence in interaction with various sugars. This experience enabled me to acquire technical and analytical skills in a pleasant working environment. I also had the opportunity to share some excellent moments with the team, both in and out of the laboratory. In conclusion, my internship with this group in Ireland was a real asset for me, both professionally and socially.

We wish Romain bon voyage and every success with the rest of his studies!

Joe Conferences, news, Presentations, Team

Thomas & Joe speak at EuChemS-9, Sophie and Hannah present posters

Research from the group was presented in two oral presentations and two poster presentations which featured in the programme of ECC-9, held at Dublin Convention Centre 7-11 July 2024. This major European conference, the largest chemistry event ever held in Ireland, had more than 1500 delegates and a wide international audience.

On the Tuesday, Thomas presented his progress on “Self-templating mechanically interlocked systems as dual activity antimicrobial candidates”, as part of the Link4Lectin project, prompting several interesting discussions with leading supramolecular chemists in attendance. Joe presented “Carbohydrate-functionalised metal complexes: targeting pathogens for therapeutic and sensing applications” as part of the Chemistry Meets Biology for Health Theme on the Thursday.

All of the team attended the meeting, with Sophie and Hannah presenting posters on their work as part of the poster sessions, Wanyujin working as a conference volunteer, and Karolina also joined the conference representing her employer Sterling. Joe judged the posters in the Catalysis theme.

Joe news, Team

Welcome to our summer students!

This summer we are joined by two visiting students from Arcadia University Study Abroad Programme and one student from Zhejiang Normal University (as part of UCD Chemistry’s ZJNU Summer School). Wanyujin is also back with us as a research assistant on the SugarCoat project. We hope it is a productive exchange for everyone!

Joe Graduations, news, Team

Karolina defends her PhD thesis

Very proud of my very first PhD student Karolina Wojtczak who successfully defended her thesis last Thursday. A lot of hard work has paid off and she has left the group lots of interesting starting points for future projects (in addition to a few more imminent publications). Her thesis was titled “Metal-based glycoconjugates as molecular sensors for lectins and anti-adhesives”.

Karol was an absolute pleasure to have in my lab and I wish her all the best with her bright future. I’m sure she will achieve great things. Congratulations!

A great celebration was had in Galway to mark the occasion.

Thanks to Research Ireland (formerly SFI) (18/SIRG/5501) for financial support and Paul Murphy for co-supervising her, particularly after I moved to UCD last year.

Karol has already started a position as a Development Chemist in Sterling Pharma Solutions.

Joe Outreach, Team

Sophie leads student visit as part of CuriosiTY programme

Sophie Kavanagh wrote about her experience hosting TY school students in our lab for some engaging science outreach as part of Systems Biology Ireland’s blog. The CuriosiTY Programme brought postgraduate researchers from the Conway Institute together to take part and introduce students to the world of STEM, and is supported by SFI Discover funding.

The week kicked off with a researcher showcase, allowing each of us researchers to show our journey in STEM, and our current areas of research.
This was followed by some laboratory breakout sessions throughout the week, where I gave 4 small groups of students hands-on experience in the world of chemistry. I decided to centre the lab session around carbon dioxide. 
The sessions began with observing the interaction of dry ice with warm, soapy water, resulting in a flurry of smoky bubbles, full of carbon dioxide.  The extinguishing power of carbon dioxide was demonstrated by placing dry ice in a beaker of water and pouring the dense gas over a lit tea candle, causing it to extinguish, showing some properties of carbon dioxide. 
Next the concept of respiration was explored, linking respiration and carbon dioxide exhalation. I pre-made some lime water for the students to experiment with. The idea here was to send home the message that even though carbon dioxide gas is a colourless, odourless and tasteless gas, we can detect its presence. Each student was given a beaker of lime water with a straw to blow bubbles and observe the colour change from colourless to milky white, and we all had a competition to see who could get their limewater to change colour the quickest.
To wrap up the laboratory session, students engaged in a ‘fire-fighting’ activity. I wanted to show an important use of carbon dioxide, and how to make carbon dioxide balloons at home with some common household items (with adult supervision of course!) Students combined a balloon full of baking soda and a bottle of white vinegar, resulting in a balloon full of carbon dioxide gas. One-by-one, a tea candle was lit and students got to release their carbon dioxide-containing balloons, extinguishing the flames. This hands-on experience allowed students to showcase their inner scientists and left them both excited and knowledgeable.
Each session was concluded with a tour of the lab, and a Q&A session where they asked me questions about chemistry, the Leaving Cert, and what a typical day in my life looks like.

Well done to Sophie for taking the initiative of taking part of this project with UCD Conway Institute.

Joe Team

Group meeting at UCD and lunch

For the first time since the group moved to UCD, we had an in-person meeting of members from Galway and UCD. Karolina was returning from a research stay in Grenoble (funded by the French embassy in Ireland) and updated us on some exciting results, which Thomas, Hannah and Wanyujin gave updates on their work. Afterwards we went out for lunch at UCD Village to talk about future plans.