Project
Link4Lectin is a four-year project that aims to exploit the unique properties of mechanically interlocked molecules (MIMs like [n]catenanes and [n]rotaxanes) to create modular hybrid compounds with potential for antimicrobial activity, by bringing together lectin-targeting and active metal complexes.
Personnel and Partners
This Starting Laureate Award was awarded to Dr Joseph Byrne in 2022. PhD students Thomas Rabbitte and Sophie Kavanagh are developing new molecules as part of this project at University College Dublin
Funding
This project is supported by the Irish Research Council as part of the Laureate Awards 2022.
Outputs
This work has also been presented at ICI Congress
Related News:
New Dalton article on Eu(III) coordination and interlocked molecules
Joe has published a new article in Dalton Transactions about “Europium-directed self-assembly of allyl bis(triazolyl)pyridine (btp) ligands”. The article describes two allyl-appended btp ligands (including a mannose-derivative). Both form luminescent europium(III) complexes with quantum yields 5.4% and 1.9% and with reasonably high stabiltiy constants.
Farewell to Jamie and Escape Room success
Jamie Casey from Alabama has completed her summer project, and the group have completed an Escape Room as part of a summer outing [click for more]
Group members present at conferences around Europe
The Byrne Group have had a busy summer attending various Conferences and Summer Schools in France, Slovakia and Italy [click image for more]
Joe speaks at Medicinal Chemistry Frontiers in Dublin
Joe delivered an oral presentation at the joint ACSMEDI-EFMC Medicinal Chemistry Frontiers conference (Trinity College Dublin) about luminescent glycoconjugate metals complexes and materials as well as some of their antiadhesive properties from lectin-targeting. The event, gathered around 400 researchers from academia and industry from the US, Europe and further afield. [click for more]
TY student completes work experience with the Group
A secondary school transition year student Matthew completed some work experience in our lab as part of his Transition Year programme, under Sophie’s guidance. [click image for more]
Joe speaks at European Glycoscience Community webinar series
Joe was invited to present recent results from the group as part of the EGC webinar series. A video of the webinar is available on YouTube.
Welcome to Rosa, Finn and Hubert
The group now has 6 full-time researchers, with the arrival of postdoc Rosa and two new PhD students Finn and Hubert. [click for details]
Lab Awarded Sustainability Certificate
The Byrne, Hooper and Phillips Groups were awarded Green Certification by MyGreenLabs as part of a Research Ireland pilot programme on sustainability [click for more]
New publication: Metallodrugs in OBC
In this article, we show how metal complexation can modulate biological activity of glycoconjugate ligands against pathogens. Well done to Karolina and our collaborators on this work [click image for more]
Thomas & Joe speak at EuChemS-9, Sophie and Hannah present posters
Thomas & Joe gave talks at ECC-9, while Sophie and Hannah presented their research in poster sessions at this major international conference. [click image for more…]
