Joe gives seminar to MIT Glycobiology Club

Joe was invited by the GlycoBio club at Massachusetts Institute of Technology about his recent article in RSC Advances, along with other work from the group. Carbohydrate researchers from MIT and other institutes in the Cambridge area tuned in to watch the talk and ask questions. Dr Adele Gabba hosted the seminar.

Joe attends Lindau Nobel Laureates Meeting

Joe attended the Lindau Nobel Laureates Meeting this June/July (thanks to the nomination of the Irish Research Council). At the week-long meeting about interdisciplinary science, from Pandemics to Blackholes, Supramolecular Chemistry to Microscopy and the cutting-edge in batteries and medicine.

As well as networking with young scientists from around the world, he was lucky enough to attend networking sessions with several Nobel laureates and have conversations about his research interests with Robert Grubbs, Richard Schrock, Ada Yonath, Ben Feringa, Saul Perlmutter and Martin Chalfie.

New article in RSC Advances: Glycoclusters with anti-biofilm activity

Our new article, published in RSC Advances (a Gold Open Access journal), describes a series of new ruthenium-centred glycoclusters, which present four carbohydrate motifs around a three-dimensional octahedral scaffold. Multivalent glycoclusters have previously shown the ability to inhibit the carbohydrate-binding proteins which are produced by bacterium P. aeruginosa. Gordon Cooke’s group in TU Dublin tested these new compounds for their ability to inhibit growth of biofilm by P. aeruginosa and we observed that complex 8Gal, with flexible arms between the scaffold core and the galactose motif gave up to 80% inhibition of biofilm, when compared to the control – the other complexes and the ligand did not show antimicrobial activity. We propose that this activity is due to the ability of galactose to interact with the carbohydrate-binding protein LecA.

We thank Science Foundation Ireland for financial support for this work, as well as UCD School of Medicine’s SSRA Scheme, where preliminary studies began.

Invited seminar at Keele University

Joe delivered a seminar to postgraduate students and academic staff at Keele University as part of their annual Seminar Series. Joe was invited to speak by Dr Chris Hawes, Lecturer in Inorganic Chemistry at Keele. The seminar was entitled “Sweetness and light: a journey towards diagnostic tools” and described the research which underpins the current work in the Byrne group as well as some recent results.

Joe speaks at Irish Biological Inorganic Chemistry Symposium

Joe gave an oral presentation about his work with carbohydrate-functionalised metal complexes at the 2020 Irish Biological Inorganic Chemistry Symposium in November. The annual IBICS meeting, and subsequent AGM, were held online this year and were well attended. Before his talk, Prof Celine Marmion, the president of IBICS, drew attention again to his role in organising the ICI Postgraduate Chemistry Research Symposium in September. The talk was followed by a number of questions from the attendees.